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.. • <br />• <br />PPG INDUSTRIES - LA PORTE PHARMACEUTICAL UNIT <br />PROJECT DESCRIPTION <br />It has been proposed to build a new pharmaceutical production unit at <br />PPG's La Porte, Texas plant site. The production unit will be used for the <br />manufacture of advanced intermediates and active pharmaceutical ingredients. <br />It is proposed to locate the unit totally within the present developed plant <br />property. If approved, construction will start in the Fall of 1998 and be <br />completed in early 2000. <br />The facility will contain multiple reactor and solids handling systems with <br />their associated ancillary equipment. Other support systems include a tank <br />farm, warehouse, truck loading and unloading facilities, refrigeration equipment, <br />and vent gas /liquid waste pre-treatment facilities. The production equipment <br />will be installed in a four level partially enclosed structure. All production <br />operations will be computer controlled. <br />As constructed, the facility will be fully compliant with EPA's <br />pharmaceutical maximum achievable control technology. Organic vent gas <br />emissions will be destroyed in the plant thermal oxidizer. Organic compounds <br />contained in the hydrogenation vent gas stream will be removed by carbon <br />adsorption. All aqueous wastes will be sent to Gulf Coast Waste Disposal <br />Authority's, Bayport Treatment Plant for biological destruction of the organics <br />contained in the effluent stream. Organic solvents used in the production <br />process will be either distilled in-house for reuse or will be sent off-site for <br />incineration. Fire protection for the facility meefs all of the IRI's requirements. <br />The facility and all chemicals used in the production process will be fully <br />permitted by the Texas Natural Resource Conservation Commission. In <br />addition, the unit will be operated to be totally compliant with the Food and Drug <br />Administration's current Good Manufacturing Practices (cGMP) guidelines. <br />Some of the chemicals that will be produced initially in the facility are: <br />1. VENLAFAXINE -This is an active ingredient used in the production of <br />an anti-depressant drug. <br />2. HYDROXY NITRILE -This is an intermediate used in the synthesis of <br />a cholesterol reducing drug. <br />3. CARBONYL DIIMIDAZOLE - an advanced carbonylating chemical. <br />4. EDOPCCL - An advanced intermediate used as a side-chain on an <br />antibiotic. <br />5. FADCP - An advanced intermediate used in the production of a <br />protease inhibitor. <br />6. PTH Carbaester - An advanced intermediate used in the production of <br />a protease inhibitor. <br />7. EIP - An intermediate used in the synthesis of platelet antagonist <br />factor drugs. <br />